Sussex's George Garton and Delray Rawlins have been selected for the 2018 North-South Series in Barbados in March.
Both players are part of a 13-man South squad to be captained by Kent captain, Sam Northeast.
James Whitaker, the National Selector who finalized the squads after discussions with coaches Paul Collingwood (North) and Mark Ramprakash (South), his fellow selectors Angus Fraser and Mick Newell, and the England and Lions coaching staff, said: "We believe these are two exciting squads which again underline the value of this North-South Series as an opportunity for us to see some strong contenders for white-ball cricket playing at a higher level of competition and intensity.
"The unavailability of several of the players who had earned automatic invitations means the squads are tilted more towards youth and potential this year.
"The North squad has six players aged 21 or under, and the South squad includes four 20-year-olds plus Sam Curran, who is still only 19.
"Some of the players we have selected have very limited List A experience with their counties. But in those cases their potential has already been identified with selection on the ECB's International Pathway.
"For example Rawlins is currently in Sydney on an Overseas Placement, and we have included three fast bowlers currently training with the Pace Programme - Zak Chappell in the North squad, and Paul Walter and Tom Helm with the South.
"But it is also a good opportunity for more experienced players who have impressed in the county game, such as Steven Mullaney, Brett D'Oliveira, John Simpson and Sam Northeast, to show the selectors and England coaches what they can do at a higher level."
The series will follow on from the one-day section of the England Lions tour of West Indies, of which George Garton is part.
The teams will each play a warm-up game on March 15th before the three-match series at the Kensington Oval on March 18th, 21st and 23rd. The Kensington Oval will also stage the MCC's Champion County match against Essex from March 27th – 30th in a spring festival of English cricket in Barbados.
North: S Mullaney (Notts, captain), S Hain (Warwickshire*), B Duckett (Northamptonshire), J Clarke (Worcestershire), K Jennings (Lancashire), B D'Oliveira (Worcestershire), A Davies (Lancashire, wk), P Coughlin (Notts), M Fisher (Yorkshire), S Mahmood (Lancashire), R Gleeson (Northamptonshire), Z Chappell (Leicestershire), M Parkinson (Lancashire).
South: S Northeast (Kent, captain), D Bell-Drummond (Kent*), N Gubbins (Middlesex), D Lawrence (Essex), Delray Rawlins (Sussex), L Dawson (Hampshire), J Simpson (Middlesex, wk), S Curran (Surrey), P Walter (Essex), D Bess (Somerset), T Helm (Middlesex), J Porter (Essex), G Garton (Sussex).